dna damage response meaning in English
dna损害反应
Examples
- Dna damage response
Dna损害反应 - Though it has been researched for almost fifty years since discoveried in 1956 , little has been known about the involvement of dna damage response pathways accounting for the radioresistance in this organism
虽然对它的特殊抗性机制有近50年的研究历史，但对于其中的分子机制仍知之甚少。 - Certain other types of immune cell seem also to become dysfunctional during aging , and again this may be because they ' ve divided often enough that dna damage responses are kicking in to stop them dividing much more
在老化期间，免疫细胞的某些其他类型似乎也变得功能障碍，这可能又是因为它们分裂太频繁，以致dna损伤反应正在起作用来停止它们分裂更多。 - Our structure and function studies on ink , cdk4 , and chk2 proteins shed great light on the mechanisms underlying some cancer diseases , while our enzymological characterizations of human and viral polymerases empower us to further understand the dna damage response and repair at dna level
从相关的特殊功能蛋白质的性质和结构研究，到dna层次的酶学?定，我们已经建立了一套完整的体内和体外研究系统，并将利用蛋白质相互作用的特点，全力发展新一代生物药物。 - The protein level of p21 increased lightly from 1 to3 h , then decreased at 6 - 9 h , reached maximum at 24 h after 2gy , it increased from 3 to 24 h exposed tology , and the protein level of p21 associated with cdk2 increased , which did not inhibit the cyclin e / cdk2 kinase activity , because of upregulation of cyclin e and deregulation of p27kipl after irradiation . in contrast to p21 , p27kipl may be a key regulator of cyclin e / cdk2 activity in dna damage responses . hi the ubiquitin - proteasome pathway invovled in regulation of p27kiplexpression in response to ir the ubiquitin - proteasome pathway regulated selective and time - controlled elimination of p27 kipl
与p27ki ” ，表达水平不同， pzi蛋白表达水平在zgy照射后略有增加， 6一gh略有下降，在照后24h达到最大; 10gy照后1一3h开始增加，持续到24h ，并且cycline / cdkz复合物中pzi蛋白结合增多，但cycline / cdkz激酶活性并未受到抑制，除了因ir诱导cydine蛋白表达水平增加外，另一重要的原因就是与pzi同一家族的p27kip ，蛋白表达水平下降，失去了对cycline / cdkz的抑制活性。